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Effects of platelet-derived growth factor and epidermal growth factor on antigen-induced proliferation of human T-cell lines.

Abstract:

When the serum content of tissue culture medium is reduced from 10% to 1%, the capacity of T cells to proliferate in response to antigen within that medium is dramatically reduced. Physiological concentrations of platelet-derived growth factor (PDGF) or epidermal growth factor (EGF) are able to partially replace the requirement for serum, in that they are able to increase antigen-driven T-cell proliferation at a serum concentration of 1%. Neither growth factor is mitogenic for T cells in the ...

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Journal:
Immunology
Volume:
54
Issue:
1
Pages:
9-16
Publication date:
1985-01-05
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:dae34369-3a89-4932-81c4-2e72035a7f07
Source identifiers:
482444
Local pid:
pubs:482444

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