Journal article icon

Journal article

Effect of the putative lithium mimetic ebselen on brain myo-inositol, sleep, and emotional processing in humans

Abstract:

Lithium remains the gold standard in treating bipolar disorder but has unwanted toxicity and side effects. We previously reported that ebselen inhibits inositol monophosphatase (IMPase) and exhibits lithium-like effects in animal models through lowering of inositol. Ebselen has been tested in clinical trials for other disorders, enabling us to determine for the first time the effect of a blood-brain barrier-penetrant IMPase inhibitor on human central nervous system (CNS) function. We now repo...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/npp.2015.343

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Expand authors...
Medical Research Council More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Neuropsychopharmacology Journal website
Volume:
41
Pages:
1768–1778
Publication date:
2016-06-01
Acceptance date:
2015-11-11
DOI:
ISSN:
0893-133X and 1740-634X
Pmid:
26593266
Language:
English
Keywords:
Pubs id:
pubs:581389
UUID:
uuid:dad58b06-5b8d-4218-9f64-901bbd60c160
Local pid:
pubs:581389
Deposit date:
2016-10-06

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP