In vivo CD8+ T cell control of immunodeficiency virus infection in humans and macaques.

Journal article

Forty million people are estimated to be infected with HIV-1, and only a small fraction of those have access to life-prolonging antiretroviral treatment. As the epidemic grows there is an urgent need for effective therapeutic and prophylactic vaccines. Nonhuman primate models of immunodeficiency virus infection are essential for the preclinical evaluation of candidate vaccines. To interpret the results of these trials, comparative studies of the human and macaque immune responses are needed. ...

Expand abstract

Authors: Asquith, B; Mclean, A

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 104
• Issue: 15
• Pages: 6365-6370
• Publication date: 2007-04-01
• DOI: 10.1073/pnas.0700666104
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: T-Lymphocytes, Cytotoxic; Simian immunodeficiency virus; Cytotoxicity, Immunologic; Macaca; Humans; Models, Immunological; Lentivirus Infections; Species Specificity; Time Factors; Mutation; Animals; Virus Replication