hsa-mir-210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer.

Journal article

BACKGROUND: Hypoxia is an important mechanism of treatment resistance in head and neck squamous cell carcinoma (HNSCC). MicroRNAs are short noncoding RNAs that regulate multiple mRNAs and are frequently dysregulated in cancer. The authors have investigated the role of 3 microRNAs, including the hypoxia-induced hsa-miR-210, as potential markers of hypoxia or prognosis. METHODS: Three hypoxia-related microRNAs, hsa-miR-210, hsa-miR-21, and hsa-miR-10b, were measured in 46 samples from patients...

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Authors: Gee, H; Camps, C; Buffa, F; Patiar, S; Winter, S

• Publication status: Published
• Journal: Cancer
• Volume: 116
• Issue: 9
• Pages: 2148-2158
• Publication date: 2010-05-01
• DOI: 10.1002/cncr.25009
• EISSN: 1097-0142
• ISSN: 0008-543X
• Language: English
• Keywords: Female; Humans; Anoxia; Gene Expression Regulation, Neoplastic; Tumor Markers, Biological; Prognosis; MicroRNAs; Adult; Male; RNA Precursors; Aged; Cell Line, Tumor; Neoplasms, Squamous Cell; Middle Aged; Aged, 80 and over; Head and Neck Neoplasms; Disease-Free Survival