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Genetic determinants of aromatase inhibitor-related arthralgia: the B-ABLE cohort study.

Abstract:

A major side effect of aromatase inhibitor (AI) therapy is AI-related arthralgia (AIA), which often leads to therapy discontinuation. We aimed to identify genetic variants associated with AIA and therapy discontinuation in the first year of AI treatment. Our prospective cohort study included 343 postmenopausal women with early breast cancer starting AI therapy. Single nucleotide polymorphisms (SNPs) in candidate genes involved in estrogen and vitamin D signaling were selected. Univariate and ...

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Publication status:
Published

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Publisher copy:
10.1007/s10549-013-2638-3

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Breast cancer research and treatment
Volume:
140
Issue:
2
Pages:
385-395
Publication date:
2013-07-05
DOI:
EISSN:
1573-7217
ISSN:
0167-6806
URN:
uuid:dabe6bac-1308-4b0f-ba6e-dcfafddee011
Source identifiers:
414774
Local pid:
pubs:414774

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