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Journal article

Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin.

Abstract:

Ferroportin (FPN) mediates iron export from cells; FPN mutations are associated with the iron overloading disorder hemochromatosis. Previously, we found that the A77D, V162del, and G490D mutations inhibited FPN activity, but that other disease-associated FPN variants retained full iron export capability. The peptide hormone hepcidin inhibits FPN as part of a homeostatic negative feedback loop. We measured surface expression and function of wild-type FPN and fully active FPN mutants in the pre...

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Publication status:
Published

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Publisher copy:
10.1182/blood-2005-02-0561

Authors


Drakesmith, H More by this author
Schimanski, LM More by this author
Ormerod, E More by this author
Merryweather-Clarke, AT More by this author
Viprakasit, V More by this author
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Journal:
Blood
Volume:
106
Issue:
3
Pages:
1092-1097
Publication date:
2005-08-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:dabd774a-869e-48f3-9cd9-501c2578ab7c
Source identifiers:
15189
Local pid:
pubs:15189

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