- Abstract:
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Deregulation of the insulin-like growth factor 1 (IGF-1) signaling pathway is a recurrent finding in mouse models and human patients with cerebellar ataxia and thus represents a common pathological cascade in neuronal cell death that may be targeted for therapy. We have previously identified a point mutation in AF4, a transcription cofactor of RNA polymerase II elongation and chromatin remodeling, that causes progressive and highly specific Purkinje cell (PC) death in the ataxic mouse mutant ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 1.3MB)
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- Publisher copy:
- 10.1523/jneurosci.5188-09.2009
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- Publisher:
- Society for Neuroscience Publisher's website
- Journal:
- Journal of Neuroscience Journal website
- Volume:
- 29
- Issue:
- 49
- Pages:
- 15366-15374
- Publication date:
- 2009-12-09
- DOI:
- EISSN:
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1529-2401
- ISSN:
-
0270-6474
- Pubs id:
-
pubs:106334
- Local pid:
- pubs:106334
- Language:
- English
- Keywords:
- Copyright holder:
- Society for Neuroscience
- Copyright date:
- 2009
- Notes:
- © 2009 Society for Neuroscience. This is an author version of the article. The final version is available online from the publisher's website
Journal article
AF4 is a critical regulator of the IGF-1 signaling pathway during Purkinje cell development
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