Universal vaccine against influenza virus: linking TLR signaling to anti-viral protection.

Journal article

A vaccine protecting against all influenza strains is a long-sought goal, particularly for emerging pandemics. As previously shown, vaccines based on the highly conserved extracellular domain of M2 (M2e) may protect against all influenza A strains. Here, we demonstrate that M2e-specific monoclonal antibodies (mAbs) protect mice from a lethal influenza infection. To be protective, antibodies had to be able to bind to Fc receptors and fix complement. Furthermore, mAbs of IgG2c isotype were prot...

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Authors: Schmitz, N; Beerli, R; Bauer, M; Jegerlehner, A; Dietmeier, K

• Journal: European journal of immunology
• Volume: 42
• Issue: 4
• Pages: 863-869
• Publication date: 2012-04-01
• DOI: 10.1002/eji.201041225
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Signal Transduction; Immunity, Innate; Orthomyxoviridae Infections; Immunoglobulin Class Switching; Humans; Mice; Pandemics; Toll-Like Receptor 7; Influenza A virus; Mice, Knockout; Immunoglobulin G; Animals; Antibodies, Viral; Membrane Glycoproteins; Influenza Vaccines; Vaccination; Antibodies, Monoclonal, Murine-Derived