Optimising the efficiency of an experimental design is known to be of great importance. However, existing methods for calculating design rank deficiency and contrast estimability (an important aspect of experimental design) relate to computational precision rather than image noise and are therefore not very meaningful. For example, a contrast between two experimental conditions may be mathematically "estimable" while requiring a huge differential BOLD response for statistical significance to ...Expand abstract
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Meaningful design and contrast estimability in FMRI.
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