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Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.

Abstract:

To this day, a significant proportion of the human genome remains devoid of functional characterization. In this study, we present evidence that the previously functionally uncharacterized product of the human DHRS10 gene is endowed with 17beta-HSD (17beta-hydroxysteroid dehydrogenase) activity. 17beta-HSD enzymes are primarily involved in the metabolism of steroids at the C-17 position and also of other substrates such as fatty acids, prostaglandins and xenobiotics. In vitro, DHRS10 converts...

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Authors


Lukacik, Petra More by this author
Keller, Brigitte More by this author
Bunkoczi, Gabor More by this author
Kavanagh, Kathryn L More by this author
Kavanagh, Kathryn More by this author
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Journal:
Biochemical Journal
Volume:
402
Issue:
3
Pages:
419-427
Publication date:
2007
ISSN:
1470-8728
URN:
uuid:da92899e-816b-40c2-8306-82a6d2ac0e29
Local pid:
SGC:17067289

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