HPMA copolymers for masking and retargeting of therapeutic viruses.

Journal article

Hydrophilic polymers are widely used already for steric stabilisation of bioactive proteins, changing their pharmacokinetics and modifying their interactions with the biological environment. Polymers may also be conjugated to biological surfaces, such as viruses, bacteria and mammalian cells, also to endow steric protection and changed properties. Reactive polymers based on N-[2-hydroxypropyl]methacrylamide have shown particular promise for surface coating of viruses, particularly adenovirus,...

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Authors: Fisher, K; Seymour, L

• Journal: Advanced drug delivery reviews
• Volume: 62
• Issue: 2
• Pages: 240-245
• Publication date: 2010-02-01
• DOI: 10.1016/j.addr.2009.12.003
• EISSN: 1872-8294
• ISSN: 0169-409X
• Language: English
• Keywords: Humans; Animals; Acrylamides; Oncolytic Virotherapy; Genetic Vectors; Adenoviridae; Drug Carriers; Polymers; Gene Targeting