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Thesis

Investigating the oncolytic properties of a group B adenovirus on cancer cells and its effects on the local immune response

Abstract:

Oncolytic viruses are characterised by their ability to selectively infect and kill tumour cells. Recently it has emerged that they can exert an additional anticancer mechanism stimulating adaptive immune-mediated cancer cell killing. Enadenotucirev (EnAd, formerly known as ColoAd1), is a chimeric Ad11p/Ad3 virus group B oncolytic adenovirus that binds CD46 and is under development for the systemic treatment of metastatic carcinomas. The central aim of this thesis was to to assess whether ...

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Hugo Calderon More by this author

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Role:
Examiner
Role:
Examiner
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Supervisor
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Grant:
FP7-29000
Funding agency for:
Hugo Calderon
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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