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A mathematical model for germinal centre kinetics and affinity maturation.

Abstract:

We present a mathematical model which reproduces experimental data on the germinal centre (GC) kinetics of the primed primary immune response and on affinity maturation observed during the reaction. We show that antigen masking by antibodies which are produced by emerging plasma cells can drive affinity maturation and provide a feedback mechanism by which the reaction is stable against variations in the initial antigen amount over several orders of magnitude. This provides a possible answer t...

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Publisher copy:
10.1006/jtbi.2002.3079

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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Journal:
Journal of theoretical biology
Volume:
219
Issue:
2
Pages:
153-175
Publication date:
2002-11-05
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
URN:
uuid:da7a2e06-3697-4c55-8673-0f6e1d96b764
Source identifiers:
7537
Local pid:
pubs:7537

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