Journal article icon

Journal article

Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells.

Abstract:

BACKGROUND: Notch signalling is essential for the development and maintenance of the colonic epithelium. Its inhibition induces a differentiation phenotype in vivo and reduces adenomas in APCmin mice. Whether Notch signals are also required in colorectal cancer (CRC) has remained elusive. Therefore, 64 CRC cell lines were analysed for the occurrence of proteolytically processed, active Notch. RESULTS: 63 CRC lines contained a fragment with approximately the size of the Notch1 intracellular d...

Expand abstract

Actions


Access Document


Publisher copy:
10.1186/1478-811x-6-8

Authors


Aleksic, T More by this author
Feller, SM More by this author
Journal:
Cell communication and signaling : CCS
Volume:
6
Issue:
1
Pages:
8
Publication date:
2008
DOI:
EISSN:
1478-811X
ISSN:
1478-811X
URN:
uuid:da74de82-eeec-4e5e-9e8b-2b79510580e5
Source identifiers:
267605
Local pid:
pubs:267605
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP