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alpha+-Thalassemia protects children against disease caused by other infections as well as malaria.

Abstract:

In the South West Pacific region, the striking geographical correlation between the frequency of alpha+-thalassemia and the endemicity of Plasmodium falciparum suggests that this hemoglobinopathy provides a selective advantage against malaria. In Vanuatu, paradoxically, alpha+-thalassemia increases the incidence of contracting mild malaria in the first 2 years of life, but severe disease was too uncommon to assess adequately. Therefore, we undertook a prospective case-control study of childre...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.94.26.14736

Authors


O'Donnell, A More by this author
Alexander, ND More by this author
Alpers, MP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine, Biomedical Research Centre
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
94
Issue:
26
Pages:
14736-14741
Publication date:
1997-12-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:da72e010-e1e8-45b0-b3f9-d57c612d9ce7
Source identifiers:
196478
Local pid:
pubs:196478

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