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Interallelic complementation at the pyrF locus and the homodimeric nature of orotate phosphoribosyltransferase (OPRTase) in Mucor circinelloides.

Abstract:

Using 5-fluoroorotic acid (5-FOA) as a positive selection system we isolated mutants of Mucor circinelloides altered in the pyrimidine biosynthetic pathway. These mutants were found to be deficient either in orotidine-5'-monophosphate decarboxylase (OMPdecase), or in orotate phosphoribosyltransferase (OPRTase) activity. Complementation tests among mutants lacking OPRTase activity classified them into three groups, thus suggesting the possibility of interallelic complementation. To investigate...

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Publisher copy:
10.1007/s004380050893

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Alvarez, MI More by this author
Eslava, AP More by this author
Iturriaga, EA More by this author
Journal:
Molecular and general genetics : MGG
Volume:
260
Issue:
2-3
Pages:
251-260
Publication date:
1998-11-05
DOI:
EISSN:
1432-1874
ISSN:
0026-8925
URN:
uuid:da724bf1-b234-4885-9899-4a4a57f23fe8
Source identifiers:
354448
Local pid:
pubs:354448

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