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SYNTHESIS OF NONPROTEINOGENIC AMINO-ACIDS .2. PREPARATION OF A SYNTHETIC EQUIVALENT OF THE GAMMA-ANION SYNTHON FOR ASYMMETRIC AMINO-ACID SYNTHESIS

Abstract:
The synthesis of α-t-butyl γ-methyl N-trityl-(S)-glutamate (12) from (S)-glutamic acid (6) is described. Diester (12), on treatment with lithium Isopropylcyclohexylamide followed by the addition of carbonyl compounds, reacts to give the γ-substituted glutamic acid derivatives (13a-i) with retention of optical purity at the α centre. © 1989.
Publication status:
Published

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Authors


BALDWIN, J More by this author
MOLONEY, M More by this author
Journal:
TETRAHEDRON
Volume:
45
Issue:
5
Pages:
1453-1464
Publication date:
1989
DOI:
ISSN:
0040-4020
URN:
uuid:da686574-2ff3-41b8-adb9-2089c5f54792
Source identifiers:
332088
Local pid:
pubs:332088
Language:
English

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