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Modulatory role for CCK-B antagonists in Parkinson's disease.

Abstract:

We examined the ability of selective CCK-A and CCK-B receptor antagonists to induce or modulate the locomotor stimulant effects of dopamine agonists in MPTP-treated squirrel monkeys. Administration of 1-100 micrograms/kg i.p. of either the selective CCK-A receptor antagonist devazepide (MK-329) or the CCK-B receptor antagonist L-365,260 alone failed to stimulate a locomotor response in parkinsonian monkeys. In contrast, treatment with L-365,260 caused a 50-60% potentiation of the locomotor st...

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Publication status:
Published

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Authors


Rupniak, NM More by this author
Steventon, MJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Clinical neuropharmacology
Volume:
13
Issue:
4
Pages:
339-347
Publication date:
1990-08-05
DOI:
EISSN:
1537-162X
ISSN:
0362-5664
URN:
uuid:da661001-7df2-42bf-9c51-8e88321eacd0
Source identifiers:
21651
Local pid:
pubs:21651

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