- Abstract:
-
We examined the ability of selective CCK-A and CCK-B receptor antagonists to induce or modulate the locomotor stimulant effects of dopamine agonists in MPTP-treated squirrel monkeys. Administration of 1-100 micrograms/kg i.p. of either the selective CCK-A receptor antagonist devazepide (MK-329) or the CCK-B receptor antagonist L-365,260 alone failed to stimulate a locomotor response in parkinsonian monkeys. In contrast, treatment with L-365,260 caused a 50-60% potentiation of the locomotor st...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1097/00002826-199008000-00009
-
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- Journal:
- Clinical neuropharmacology
- Volume:
- 13
- Issue:
- 4
- Pages:
- 339-347
- Publication date:
- 1990-08-05
- DOI:
- EISSN:
-
1537-162X
- ISSN:
-
0362-5664
- URN:
-
uuid:da661001-7df2-42bf-9c51-8e88321eacd0
- Source identifiers:
-
21651
- Local pid:
- pubs:21651
- Copyright date:
- 1990
Journal article
Modulatory role for CCK-B antagonists in Parkinson's disease.
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