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The impact of renin-angiotensin-aldosterone system inhibitors on Type 1 and Type 2 diabetic patients with and without early diabetic nephropathy

Abstract:

Renin-angiotensin-aldosterone system inhibitors prevent the progression of kidney disease in patients with diabetic nephropathy, and we studied how that benefit varies by the type of diabetes and baseline urinary albumin. We pooled data from 49 randomized controlled trials in a meta-analysis using the ratio of endpoint urinary albumin levels in those treated compared to those untreated with renin-angiotensin-aldosterone system inhibitors in both fixed- and random-effects models. The urinary a...

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Publisher copy:
10.1038/ki.2011.413

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Stats
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Stats
Role:
Author
More by this author
Institution:
University of Oxford
Department:
MSD, Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
MSD, Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
MSD, Primary Care Health Sciences
Role:
Author
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Journal:
Kidney International
Volume:
81
Issue:
7
Pages:
674-683
Publication date:
2012-04-01
DOI:
EISSN:
1523-1755
ISSN:
0085-2538
URN:
uuid:da65d651-923d-4b08-b20c-cf97c42e3b82
Source identifiers:
321385
Local pid:
pubs:321385

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