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Journal article

Evidence both L-type and non-L-type voltage-dependent calcium channels contribute to cerebral artery vasospasm following loss of NO in the rat.

Abstract:

We recently found block of NO synthase in rat middle cerebral artery caused spasm, associated with depolarizing oscillations in membrane potential (E(m)) similar in form but faster in frequency (circa 1 Hz) to vasomotion. T-type voltage-gated Ca(2+) channels contribute to cerebral myogenic tone and vasomotion, so we investigated the significance of T-type and other ion channels for membrane potential oscillations underlying arterial spasm. Smooth muscle cell membrane potential (E(m)) and tens...

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Publication status:
Published

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Publisher copy:
10.1016/j.vph.2010.06.002

Authors


McNeish, AJ More by this author
Altayo, FJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Journal:
Vascular pharmacology
Volume:
53
Issue:
3-4
Pages:
151-159
Publication date:
2010
DOI:
EISSN:
1879-3649
ISSN:
1537-1891
URN:
uuid:da64b89c-4d88-466a-a6a8-3484fa71a8e5
Source identifiers:
106503
Local pid:
pubs:106503

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