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The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation

Abstract:

C-1311 is a small molecule, which has shown promise in a number of pre-clinical and clinical studies. However, the biological response to C-1311 exposure is complicated and has been reported to involve a number of cell fates. Here, we investigated the molecular signaling which determines the response to C-1311 in both cancer and non-cancer cell lines. For the first time we demonstrate that the tumor suppressor, p53 plays a key role in cell fate determination after C-1311 treatment. In the pre...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.18632/oncotarget.16102

Authors


Skwarska, A More by this author
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Department:
Oxford, MSD, Oncology
More by this author
Department:
Oxford, MSD, Oncology
More by this author
Department:
Oxford, MSD, Oncology
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Department:
Oxford, MSD, Oncology
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Funding agency for:
Hammond, EM
Publisher:
Impact Journals Publisher's website
Journal:
Oncotarget Journal website
Volume:
8
Issue:
19
Pages:
31187-31198
Publication date:
2017
Acceptance date:
2017-03-02
DOI:
ISSN:
1949-2553
Pubs id:
pubs:686273
URN:
uri:da626025-4e37-4a04-9659-132761bfce01
UUID:
uuid:da626025-4e37-4a04-9659-132761bfce01
Local pid:
pubs:686273

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