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Journal article

Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP.

Abstract:

Most human protein-encoding genes contain multiple exons that are spliced together, frequently in alternative arrangements, by the spliceosome. It is established that U1 snRNP is an essential component of the spliceosome, in human consisting of RNA and ten proteins, several of which are post-translationally modified and exist as multiple isoforms. Unresolved and challenging to investigate are the effects of these post translational modifications on the dynamics, interactions and stability of ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0007202

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Funding agency for:
Robinson, CV
Biotechnology and Biological Sciences Research Council More from this funder
Engineering and Physical Sciences Research Council More from this funder
EU Prospects More from this funder
European Science Foundation More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
4
Issue:
9
Pages:
e7202
Publication date:
2009-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:da5a71fa-6e49-4e53-8c4f-bcbfc34ab0b9
Source identifiers:
59332
Local pid:
pubs:59332

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