- Abstract:
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Most human protein-encoding genes contain multiple exons that are spliced together, frequently in alternative arrangements, by the spliceosome. It is established that U1 snRNP is an essential component of the spliceosome, in human consisting of RNA and ten proteins, several of which are post-translationally modified and exist as multiple isoforms. Unresolved and challenging to investigate are the effects of these post translational modifications on the dynamics, interactions and stability of ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 1.2MB)
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- Publisher copy:
- 10.1371/journal.pone.0007202
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 4
- Issue:
- 9
- Pages:
- e7202
- Publication date:
- 2009-01-01
- DOI:
- EISSN:
-
1932-6203
- ISSN:
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1932-6203
- URN:
-
uuid:da5a71fa-6e49-4e53-8c4f-bcbfc34ab0b9
- Source identifiers:
-
59332
- Local pid:
- pubs:59332
- Language:
- English
- Keywords:
- Copyright holder:
- Hernandez et al.
- Copyright date:
- 2009
- Notes:
- Copyright 2009 Hernandez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP.
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