Journal article
Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP.
- Abstract:
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Most human protein-encoding genes contain multiple exons that are spliced together, frequently in alternative arrangements, by the spliceosome. It is established that U1 snRNP is an essential component of the spliceosome, in human consisting of RNA and ten proteins, several of which are post-translationally modified and exist as multiple isoforms. Unresolved and challenging to investigate are the effects of these post translational modifications on the dynamics, interactions and stability of ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.2MB)
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- Publisher copy:
- 10.1371/journal.pone.0007202
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Authors
Funding
Engineering and Physical Sciences Research Council
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Biotechnology and Biological Sciences Research Council
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European Science Foundation
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Royal Society
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 4
- Issue:
- 9
- Article number:
- e7202
- Publication date:
- 2009-01-01
- DOI:
- EISSN:
-
1932-6203
- ISSN:
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1932-6203
- Source identifiers:
-
59332
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:da5a71fa-6e49-4e53-8c4f-bcbfc34ab0b9
- Local pid:
- pubs:59332
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Hernandez et al
- Copyright date:
- 2009
- Notes:
- Copyright 2009 Hernandez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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