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CD45 is required for type I IFN production by dendritic cells.

Abstract:

CD45 is a leukocyte tyrosine phosphatase, essential for normal immune responses. We have studied the function of splenic dendritic cells of CD45(+/+), CD45(-/-), CD45RABC and CD45RO transgenic mice. We show that there are increased numbers of plasmacytoid dendritic cells in CD45(-/-) mice. DC of all mice are capable of responding to lymphocytic choriomeningitis virus (LCMV) infection by up-regulation of MHC and costimulatory molecules. DC of CD45(-/-) mice have an impaired capacity to produce...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200535304

Authors


Montoya, M More by this author
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Journal:
European journal of immunology
Volume:
36
Issue:
8
Pages:
2150-2158
Publication date:
2006-08-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:da581ebf-de47-48a0-8e73-894871d41662
Source identifiers:
33558
Local pid:
pubs:33558

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