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Journal article

Structure, function, and evolution of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein

Abstract:

Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging tick-borne virus of the Bunyaviridae family that is responsible for a fatal human disease for which preventative or therapeutic measures do not exist. We solved the crystal structure of the CCHFV strain Baghdad-12 nucleocapsid protein (N), a potential therapeutic target, at a resolution of 2.1 Å. N comprises a large globular domain composed of both N- and C-terminal sequences, likely involved in RNA binding, and a protruding arm dom...

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Publication status:
Published

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Publisher copy:
10.1128/JVI.01555-12

Authors


Carter, SD More by this author
Surtees, R More by this author
Walter, CT More by this author
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Department:
Oxford, MSD, Pathology Dunn School
Bergeron, É More by this author
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Virology
Volume:
86
Issue:
20
Pages:
10914-10923
Publication date:
2012-10-02
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Pubs id:
pubs:659852
URN:
uri:da532bff-9006-41bf-bd4c-dcb227576d29
UUID:
uuid:da532bff-9006-41bf-bd4c-dcb227576d29
Local pid:
pubs:659852
Language:
English
Keywords:

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