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Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes.

Abstract:

A number of rat monoclonal antibodies of the IgG2b subclass have been used to deplete mice of T lymphocyte subsets. It has been possible to produce long-term depletion where antibodies are administered to mice thymectomized in their adult life, or short-term depletion in euthymic animals. It is therefore feasible to ablate a T lymphocyte subpopulation at any stage in the course of an immune response and to examine in detail the role of a particular subset in the induction or effector phases o...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Cobbold, S More by this author
Benjamin, R More by this author
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Journal:
Ciba Foundation symposium
Volume:
129
Pages:
194-208
Publication date:
1987
ISSN:
0300-5208
URN:
uuid:da4c6df5-6b15-44c0-bf95-7d83ecdbfab0
Source identifiers:
15798
Local pid:
pubs:15798

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