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Characterization of ligand binding by the human p55 tumour-necrosis-factor receptor. Involvement of individual cysteine-rich repeats.

Abstract:

Two soluble tumour-necrosis-factor-alpha(TNF)-binding proteins are derived from the extracellular domains of the p55 and p75 TNF receptors. They are considered to play a pivotal regulatory role in TNF-mediated inflammatory processes, including diseases such as rheumatoid arthritis, by competing with the cell surface receptors for TNF and lymphotoxin (LT, tumour-necrosis factor beta). The extracellular domains of the two receptors each contain four similar cysteine-rich repeats of about 40 ami...

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Publication status:
Published

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Journal:
European journal of biochemistry / FEBS
Volume:
223
Issue:
3
Pages:
831-840
Publication date:
1994-08-05
DOI:
EISSN:
1432-1033
ISSN:
0014-2956
URN:
uuid:da416ef3-edef-4cbe-98d2-a748ab8754d0
Source identifiers:
481661
Local pid:
pubs:481661

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