Journal article icon

Journal article

Lopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adults.

Abstract:

BACKGROUND: Treatment of HIV/malaria-coinfected patients with antiretroviral therapy (ART) and artemisinin-based combination therapy has potential for drug interactions. We investigated the pharmacokinetics of artemether, dihydroartemisinin and lumefantrine after administration of a single dose of 80/480 mg of artemether/lumefantrine to HIV-infected adults, taken with and without lopinavir/ritonavir. METHODS: A two-arm parallel study of 13 HIV-infected ART-naive adults and 16 HIV-infected adu...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/jac/dkr596

Authors


Byakika-Kibwika, P More by this author
Lamorde, M More by this author
Okaba-Kayom, V More by this author
Mayanja-Kizza, H More by this author
Katabira, E More by this author
Expand authors...
Journal:
The Journal of antimicrobial chemotherapy
Volume:
67
Issue:
5
Pages:
1217-1223
Publication date:
2012-05-05
DOI:
EISSN:
1460-2091
ISSN:
0305-7453
URN:
uuid:da33aa60-8247-4ad1-8b31-ff71beb35fff
Source identifiers:
254274
Local pid:
pubs:254274

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP