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The macrophage scavenger receptor at 30 years of age: current knowledge and future challenges.

Abstract:

It is now thirty years since the original observation that macrophages take up and degrade modified forms of low density lipoprotein (LDL). Molecular cloning has identified multiple scavenger receptors that can endocytose modified LDL and binding studies continue to identify a wide range of scavenger receptor ligands displayed by bacterial pathogens, modified self proteins and apoptotic cells. Scavenger receptors drive macrophage foam cell development in vitro but their exact role in the deve...

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Publication status:
Published

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Publisher copy:
10.1194/jlr.r800066-jlr200

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School, BHF Centre of Research Excellence
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Journal of lipid research
Volume:
50 Suppl
Issue:
Supplement
Pages:
S282-S286
Publication date:
2009-04-05
DOI:
ISSN:
0022-2275
URN:
uuid:da17a1d1-15d5-42bd-99fc-96ce21cbf8c5
Source identifiers:
30203
Local pid:
pubs:30203

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