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Journal article

Iron genes, iron load and risk of Alzheimer's disease.

Abstract:

BACKGROUND: Compound heterozygotes of the haemochromatosis gene (HFE) variants, H63D and C282Y, have raised transferrin saturation compared with that in the wild type. In the cohort of the Oxford Project To Investigate Memory and Ageing (OPTIMA), bicarriers of the HFE C282Y and the transferrin C2 gene variants are at five times greater risk of developing Alzheimer's disease; the addition of HFE H63D may raise the risk still further. OBJECTIVE: To investigate transferrin saturation by HFE and...

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Publication status:
Published

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Publisher copy:
10.1136/jmg.2006.040519

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Journal:
Journal of medical genetics
Volume:
43
Issue:
10
Pages:
e52
Publication date:
2006-10-05
DOI:
EISSN:
1468-6244
ISSN:
0022-2593
URN:
uuid:da125dc3-ccff-49a0-9b17-a346b6709625
Source identifiers:
157797
Local pid:
pubs:157797

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