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Examining the conservation of kinks in alpha helices

Abstract:

Kinks are a structural feature of alpha-helices and many are known to have functional roles. Kinks have previously tended to be defined in a binary fashion. In this paper we have deliberately moved towards defining them on a continuum, which given the unimodal distribution of kink angles is a better description. From this perspective, we examine the conservation of kinks in proteins. We find that kink angles are not generally a conserved property of homologs, pointing either to their not bein...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0157553

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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
11
Issue:
6
Pages:
Article: e0157553
Publication date:
2016
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:da0ef4b1-9e1d-40a6-a56d-fb3ddead2ef7
Source identifiers:
628916
Local pid:
pubs:628916

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