Serial, noninvasive, in vivo magnetic resonance microscopy detects the development of atherosclerosis in apolipoprotein E-deficient mice and its progression by arterial wall remodeling.

Journal article

PURPOSE: To test the ability of serial, in vivo magnetic resonance microscopy (MRM) to detect the development of atherosclerosis and quantify its progression in apolipoprotein E-deficient mice. MATERIALS AND METHODS: The abdominal aortae of six ApoE(-/-) and three wild-type (WT) control mice were imaged by MRM at 9.4T. Proton density weighted images were obtained (TR = 2000, TE = 9 msec) using four signal averages. The image resolution was 109 x 109 x 500 microm(3). The six ApoE(-/-) mice un...

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Authors: Choudhury, R; Fayad, Z; Aguinaldo, J; Itskovich, V; Rong, J

• Publication status: Published
• Journal: Journal of magnetic resonance imaging : JMRI
• Volume: 17
• Issue: 2
• Pages: 184-189
• Publication date: 2003-02-01
• DOI: 10.1002/jmri.10246
• EISSN: 1522-2586
• ISSN: 1053-1807
• Language: English
• Keywords: Animals; Female; Magnetic Resonance Spectroscopy; Apolipoproteins E; Mice, Inbred C57BL; Aorta, Abdominal; Mice; Arteriosclerosis