The emergence and maintenance of sickle cell hotspots in the Mediterranean.

Journal article

Genetic disorders of haemoglobin (haemoglobinopathies), including the thalassaemias and sickle cell anaemia, abound in historically malarious regions, due to the protection they provide against death from severe malaria. Despite the overall spatial correlation between malaria and these disorders, inter-population differences exist in the precise combinations of haemoglobinopathies observed. Greece and Italy present a particularly interesting case study: their high frequencies of beta thalassa...

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Authors: Penman, B; Gupta, S; Buckee, C

• Publication status: Published
• Journal: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
• Volume: 12
• Issue: 7
• Pages: 1543-1550
• Publication date: 2012-10-01
• DOI: 10.1016/j.meegid.2012.06.001
• EISSN: 1567-7257
• ISSN: 1567-1348
• Language: English
• Keywords: alpha-Thalassemia; Computer Simulation; Mediterranean Islands; Gene Flow; beta-Thalassemia; Mediterranean Region; Greece; Gene Frequency; Italy; Endemic Diseases; Models, Genetic; Epistasis, Genetic