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Immune response to the ALK oncogenic tyrosine kinase in patients with anaplastic large-cell lymphoma.

Abstract:

Oncogenic anaplastic lymphoma kinase (ALK) fusion proteins (nucleophosmin-ALK [NPM-ALK] and other variants) are expressed in many cases of anaplastic large-cell lymphoma (ALCL) but are absent from normal tissues. The possibility that ALK proteins are immunogenic was investigated with the use of an immunocytochemical technique to screen plasma from ALK-positive ALCL on transfectants expressing ALK proteins and by an in vitro kinase assay. Circulating antibodies against NPM-ALK protein were pre...

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Authors


Pulford, K More by this author
Banham, AH More by this author
Codrington, D More by this author
Roberton, H More by this author
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Journal:
Blood
Volume:
96
Issue:
4
Pages:
1605-1607
Publication date:
2000-08-05
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:d9f82dd1-390e-469f-b24b-b4115795d923
Source identifiers:
246345
Local pid:
pubs:246345

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