Journal article
DNA methylation and Rett syndrome.
- Abstract:
- Methylation of cytosine in human DNA has been studied for over 60 years, but has only recently been confirmed as an important player in human disease. Rett syndrome is a neurological disorder caused by mutations in the MeCP2 protein, which has been shown to bind methylated DNA and repress transcription. This review will focus on experiments addressing the basic properties of MeCP2 and on mouse models of Rett syndrome that are starting to yield insights into this condition.
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- Publisher copy:
- 10.1093/hmg/ddg286
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Bibliographic Details
- Journal:
- Human molecular genetics
- Volume:
- 12 Spec No 2
- Issue:
- suppl 2
- Pages:
- R221-R227
- Publication date:
- 2003-10-01
- DOI:
- EISSN:
-
1460-2083
- ISSN:
-
0964-6906
- Source identifiers:
-
90262
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:90262
- UUID:
-
uuid:d9eb60bb-d10f-47a2-afa9-24e944ecad6c
- Local pid:
- pubs:90262
- Deposit date:
- 2013-02-20
Terms of use
- Copyright date:
- 2003
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