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Survival motor neuron protein regulates stem cell division, proliferation, and differentiation in Drosophila.

Abstract:

Spinal muscular atrophy is a severe neurogenic disease that is caused by mutations in the human survival motor neuron 1 (SMN1) gene. SMN protein is required for the assembly of small nuclear ribonucleoproteins and a dramatic reduction of the protein leads to cell death. It is currently unknown how the reduction of this ubiquitously essential protein can lead to tissue-specific abnormalities. In addition, it is still not known whether the disease is caused by developmental or degenerative defe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1002030

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Institution:
University of Oxford
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Medical Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
7
Issue:
4
Pages:
Article: e1002030
Publication date:
2011
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:d9e96c1a-9cc5-4ecd-8d48-4c59ace95019
Source identifiers:
149835
Local pid:
pubs:149835

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