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Molecular dynamics simulations of DNA within a nanopore: arginine-phosphate tethering and a binding/sliding mechanism for translocation.

Abstract:

Protein nanopores show great potential as low-cost detectors in DNA sequencing devices. To date, research has largely focused on the staphylococcal pore α-hemolysin (αHL). In the present study, we have developed simplified models of the wild-type αHL pore and various mutants in order to study the translocation dynamics of single-stranded DNA under the influence of an applied electric field. The model nanopores reflect the experimentally measured conductance values in planar lipid bilayers. We...

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Publication status:
Published

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Publisher copy:
10.1021/bi101404n

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Journal:
Biochemistry
Volume:
50
Issue:
18
Pages:
3777-3783
Publication date:
2011-05-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:d9ddd0ba-ab95-42b9-b9a0-ac88d42289ab
Source identifiers:
146629
Local pid:
pubs:146629

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