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Matrix Degradation in Human Immunodeficiency Virus Type 1-Associated Tuberculosis and Tuberculosis Immune Reconstitution Inflammatory Syndrome: A Prospective Observational Study.

Abstract:

Background.
Extensive immunopathology occurs in human immunodeficiency virus (HIV)/tuberculosis (TB) coinfection, but the underlying molecular mechanisms are not well-defined. Excessive matrix metalloproteinase (MMP) activity is emerging as a key process but has not been systematically studied in HIV-associated TB.

Methods.
We performed a cross-sectional study of matrix turnover in HIV type 1 (HIV-1)–infected and –uninfected TB patients and controls, and a prospective coho...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/cid/cix231

Authors


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Grant:
203135, 094000, 104803, 098316, FC00110218
National Institute for Health Research More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Clinical Infectious Diseases Journal website
Publication date:
2017-05-05
Acceptance date:
2017-03-29
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Pubs id:
pubs:694015
URN:
uri:d9d35ce8-3960-4a9b-9573-ac34e4010271
UUID:
uuid:d9d35ce8-3960-4a9b-9573-ac34e4010271
Local pid:
pubs:694015

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