Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors.

Journal article

Wntbeta-catenin signaling plays key roles in several developmental and pathological processes. Domains of Wnt expression have been extensively investigated in the mouse, but the tissues receiving the signal remain largely unidentified. To define which cells respond to activated beta-catenin during mammalian development, we generated the beta-catenin-activated transgene driving expression of nuclear beta-galactosidase reporter (BAT-gal) transgenic mice, expressing the lacZ gene under the contr...

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Authors: Maretto, S; Cordenonsi, M; Dupont, S; Braghetta, P; Broccoli, V

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 100
• Issue: 6
• Pages: 3299-3304
• Publication date: 2003-03-07
• DOI: 10.1073/pnas.0434590100
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Colorectal Neoplasms; Proto-Oncogene Proteins; Nervous System; Wnt Proteins; Cytoskeletal Proteins; Zebrafish Proteins; Animals; Signal Transduction; Mice; beta Catenin; Genes, Reporter; Mutation; Mice, Transgenic; In Situ Hybridization; Gene Expression Regulation, Developmental; Trans-Activators; Lac Operon