- Abstract:
-
The Notch receptor is a key component of a core metazoan signalling pathway activated by Delta/Serrate/Lag-2 ligands expressed on an adjacent cell. This results in a short-range signal with profound effects on cell-fate determination, cell proliferation and cell death. Key to understanding receptor function is structural knowledge of the large extracellular portion of Notch containing multiple repeats of epidermal growth factor (EGF)-like domains. Here we investigate the EGF4-13 region of hum...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.4MB)
-
- Publisher copy:
- 10.1016/j.str.2016.02.010
-
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- Publisher:
- Elsevier (Cell Press) Publisher's website
- Journal:
- Structure Journal website
- Volume:
- 24
- Issue:
- 4
- Pages:
- 555–566
- Publication date:
- 2016-03-17
- DOI:
- EISSN:
-
1878-4186
- ISSN:
-
0969-2126
- URN:
-
uuid:d9cf4776-4645-443e-b66a-5e2212015cdc
- Source identifiers:
-
602503
- Local pid:
- pubs:602503
- Paper number:
- 4
- Copyright holder:
- Weisshuhn et al.
- Copyright date:
- 2016
- Notes:
- © 2016 The Authors. Published by Elsevier Inc. Open access funded by Wellcome Trust, available under a Creative Commons Attribution (CC BY 4.0) Licence.
Journal article
Non-linear and flexible regions of the human Notch-1 extracellular domain revealed by high-resolution structural studies
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