Journal article
Non-linear and flexible regions of the human Notch-1 extracellular domain revealed by high-resolution structural studies
- Abstract:
-
The Notch receptor is a key component of a core metazoan signalling pathway activated by Delta/Serrate/Lag-2 ligands expressed on an adjacent cell. This results in a short-range signal with profound effects on cell-fate determination, cell proliferation and cell death. Key to understanding receptor function is structural knowledge of the large extracellular portion of Notch containing multiple repeats of epidermal growth factor (EGF)-like domains. Here we investigate the EGF4-13 region of hum...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 2.4MB)
-
- Publisher copy:
- 10.1016/j.str.2016.02.010
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Structure Journal website
- Volume:
- 24
- Issue:
- 4
- Pages:
- 555–566
- Publication date:
- 2016-03-17
- DOI:
- EISSN:
-
1878-4186
- ISSN:
-
0969-2126
- Source identifiers:
-
602503
Item Description
- Pubs id:
-
pubs:602503
- UUID:
-
uuid:d9cf4776-4645-443e-b66a-5e2212015cdc
- Local pid:
- pubs:602503
- Deposit date:
- 2016-02-15
Terms of use
- Copyright holder:
- Weisshuhn et al
- Copyright date:
- 2016
- Notes:
- © 2016 The Authors. Published by Elsevier Inc. Open access funded by Wellcome Trust, available under a Creative Commons Attribution (CC BY 4.0) Licence.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record