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Non-linear and flexible regions of the human Notch-1 extracellular domain revealed by high-resolution structural studies

Abstract:

The Notch receptor is a key component of a core metazoan signalling pathway activated by Delta/Serrate/Lag-2 ligands expressed on an adjacent cell. This results in a short-range signal with profound effects on cell-fate determination, cell proliferation and cell death. Key to understanding receptor function is structural knowledge of the large extracellular portion of Notch containing multiple repeats of epidermal growth factor (EGF)-like domains. Here we investigate the EGF4-13 region of hum...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.str.2016.02.010

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Funding agency for:
Redfield, C
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Funding agency for:
Redfield, C
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Funding agency for:
Weisshuhn, PC
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Funding agency for:
Handford, PA
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Funding agency for:
Handford, PA
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Publisher:
Elsevier (Cell Press) Publisher's website
Journal:
Structure Journal website
Volume:
24
Issue:
4
Pages:
555–566
Publication date:
2016-03-17
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:d9cf4776-4645-443e-b66a-5e2212015cdc
Source identifiers:
602503
Local pid:
pubs:602503
Paper number:
4

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