Journal article icon

Journal article

Blockade of α2-adrenoceptors induces Arc gene expression in rat brain in a glutamate receptor-dependent manner: a combined qPCR, in situ hybridisation and immunocytochemistry study.

Abstract:

Studies of 5-HT-glutamate interactions suggest that activation of brain 5-HT(2A) receptors leads to an AMPA receptor-mediated induction of the immediate early (activity-dependent) gene, Arc (Arg3.1). In this respect, noradrenaline-glutamate interactions are poorly characterised. Here we investigated the influence on regional brain Arc gene expression of selective blockade of α(2)-adrenoceptors in rats. Several complementary techniques were used: qPCR (mRNA, discrete tissue punches), in situ h...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Rodriguez, M More by this author
Galizzi, JP More by this author
Lockhart, B More by this author
Expand authors...
Journal:
Neuropharmacology
Volume:
63
Issue:
6
Pages:
992-1001
Publication date:
2012-11-05
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
URN:
uuid:d9c59fee-1f49-4f5f-8498-c9008c7cc6c1
Source identifiers:
343923
Local pid:
pubs:343923

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP