Induction of potent antitumor CTL responses by recombinant vaccinia encoding a melan-A peptide analogue.

Journal article

There is considerable interest in the development of vaccination strategies that would elicit strong tumor-specific CTL responses in cancer patients. One strategy consists of using recombinant viruses encoding amino acid sequences corresponding to natural CTL-defined peptide from tumor Ags as immunogens. However, studies with synthetic tumor antigenic peptides have demonstrated that introduction of single amino acid substitutions may dramatically increase their immunogenicity. In this study w...

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Authors: Valmori, D; Lévy, F; Miconnet, I; Zajac, P; Spagnoli, G

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 164
• Issue: 2
• Pages: 1125-1131
• Publication date: 2000-01-01
• DOI: 10.4049/jimmunol.164.2.1125
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Amino Acid Sequence; Lymphocyte Activation; Injections, Intraperitoneal; Peptides; Epitopes, T-Lymphocyte; Antigens, Neoplasm; Vaccinia virus; T-Lymphocytes, Cytotoxic; Mutagenesis, Site-Directed; Molecular Sequence Data; Vaccines, Synthetic; Animals; Cancer Vaccines; MART-1 Antigen; Mice, Transgenic; Ubiquitins; Genetic Vectors; Melanoma; Mice; Humans; Genes, Synthetic; Antigen-Presenting Cells; Tumor Cells, Cultured; Viral Vaccines; Cytotoxicity, Immunologic; Neoplasm Proteins