Journal article : Review
Probing membrane protein-lipid interactions
- Abstract:
- Structure determination of membrane proteins has highlighted the many roles played by lipids in influencing overall protein architecture. It is now widely accepted that lipids surrounding membrane proteins play crucial roles by modulating their conformational, structural, and functional properties. Capturing often transient lipid interactions and defining their chemical identity, however, remains challenging. Recent advances in mass spectrometry have resolved questions concerning lipid interactions by providing the molecular composition of intact complexes in association with lipids. Together with other biophysical tools, a picture is emerging of the dynamic nature of lipid-mediated interactions and their effects on conformation, interactions, and signaling.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
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(Preview, Accepted manuscript, 371.1KB, Terms of use)
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- Publisher copy:
- 10.1016/j.sbi.2021.03.010
Authors
- Publisher:
- Elsevier
- Journal:
- Current Opinion in Structural Biology More from this journal
- Volume:
- 69
- Pages:
- 78-85
- Publication date:
- 2021-04-27
- Acceptance date:
- 2021-03-21
- DOI:
- EISSN:
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1879-033X
- ISSN:
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0959-440X
- Pmid:
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33930613
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1176466
- Local pid:
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pubs:1176466
- Deposit date:
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2021-06-18
Terms of use
- Copyright holder:
- Elsevier Ltd.
- Copyright date:
- 2021
- Rights statement:
- © 2021 Published by Elsevier Ltd.
- Notes:
-
This is the accepted manuscript version of the article. The final version is available from Elsevier at https://doi.org/10.1016/j.sbi.2021.03.010
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