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Modulation of Na+-H+ exchange isoforms NHE1 and NHE3 by insulin-like growth factor-1 in isolated bovine articular chondrocytes.

Abstract:

Incubation with serum modulates the transporters that regulate intracellular pH (pH(i)) in articular chondrocytes, upregulating acid extrusion by Na(+)-H(+) exchange (NHE). There is stimulation of NHE1, together with induction of NHE3 activity. These isoforms exhibit differential responses to components of mechanical load experienced by chondrocytes during joint loading. The identity of the component(s) of serum responsible is unknown. A possibility, however, is insulin-like growth factor-1 (...

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Publication status:
Published

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Publisher copy:
10.1002/jor.20617

Authors


Tattersall, AL More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Volume:
26
Issue:
11
Pages:
1428-1433
Publication date:
2008-11-05
DOI:
EISSN:
1554-527X
ISSN:
0736-0266
URN:
uuid:d9b94041-aee2-4713-b5e1-6359949fd9d7
Source identifiers:
113764
Local pid:
pubs:113764

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