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Prevention of pathology in mdx mice by expression of utrophin: analysis using an inducible transgenic expression system.

Abstract:

Duchenne muscular dystrophy results from the absence of dystrophin, a cytoskeletal protein. Previously, we have shown in a transgenic mouse model of the disease (mdx) that high levels of expression of the dystrophin-related protein, utrophin can prevent pathology. We developed a new transgenic mouse model where muscle specific utrophin expression was conditioned by addition of tetracycline in water. Transgene expression was turned on at different time points: in utero, at birth, 10 and 30 day...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/11.26.3333

Authors


Raymackers, JM More by this author
Vandebrouck, C More by this author
Tinsley, J More by this author
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Journal:
Human molecular genetics
Volume:
11
Issue:
26
Pages:
3333-3344
Publication date:
2002-12-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:d9a7df23-e23d-457b-b107-95defd0be146
Source identifiers:
106500
Local pid:
pubs:106500

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