Journal article
Prevention of pathology in mdx mice by expression of utrophin: analysis using an inducible transgenic expression system.
- Abstract:
-
Duchenne muscular dystrophy results from the absence of dystrophin, a cytoskeletal protein. Previously, we have shown in a transgenic mouse model of the disease (mdx) that high levels of expression of the dystrophin-related protein, utrophin can prevent pathology. We developed a new transgenic mouse model where muscle specific utrophin expression was conditioned by addition of tetracycline in water. Transgene expression was turned on at different time points: in utero, at birth, 10 and 30 day...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/hmg/11.26.3333
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Authors
Bibliographic Details
- Journal:
- Human molecular genetics
- Volume:
- 11
- Issue:
- 26
- Pages:
- 3333-3344
- Publication date:
- 2002-12-05
- DOI:
- EISSN:
-
1460-2083
- ISSN:
-
0964-6906
- URN:
-
uuid:d9a7df23-e23d-457b-b107-95defd0be146
- Source identifiers:
-
106500
- Local pid:
- pubs:106500
Item Description
Terms of use
- Copyright date:
- 2002
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