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Functional nuclear organization of transcription and DNA replication: a topographical marriage between chromatin domains and the interchromatin compartment.

Abstract:

We studied the nuclear topography of RNA transcription and DNA replication in mammalian cell types with super-resolution fluorescence microscopy, which offers a resolution beyond the classical Abbe/Raleigh limit. Three-dimensional structured illumination microscopy (3D-SIM) demonstrated a network of channels and wider lacunas, called the interchromatin compartment (IC). The IC starts at nuclear pores and expands throughout the nuclear space. It is demarcated from the compact interior of highe...

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Publisher copy:
10.1101/sqb.2010.75.042

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Journal:
Cold Spring Harbor symposia on quantitative biology
Volume:
75
Issue:
0
Pages:
475-492
Publication date:
2010-01-01
DOI:
EISSN:
1943-4456
ISSN:
0091-7451
URN:
uuid:d995b1e4-38fe-48f9-933a-3e4995d2c3bf
Source identifiers:
310434
Local pid:
pubs:310434

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