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Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.

Abstract:

Patients with glucocorticoid excess develop central obesity, yet in simple obesity, circulating glucocorticoid levels are normal. We have suggested that the increased activity and expression of the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) generating active cortisol from cortisone within adipose tissue may be crucial in the pathogenesis of obesity. In this study primary cultures of human hepatocytes and adipose stromal cells (ASC) were used as in vitro models to investiga...

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Publication status:
Published

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Publisher copy:
10.1210/en.142.5.1982

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Cooper, MS More by this author
Bujalska, I More by this author
Shahmanesh, M More by this author
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Journal:
Endocrinology
Volume:
142
Issue:
5
Pages:
1982-1989
Publication date:
2001-05-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:d98781f6-3cf1-49a0-8f9c-2a6b22e6c575
Source identifiers:
125899
Local pid:
pubs:125899

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