Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines.

Journal article

Patients with glucocorticoid excess develop central obesity, yet in simple obesity, circulating glucocorticoid levels are normal. We have suggested that the increased activity and expression of the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) generating active cortisol from cortisone within adipose tissue may be crucial in the pathogenesis of obesity. In this study primary cultures of human hepatocytes and adipose stromal cells (ASC) were used as in vitro models to investiga...

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Authors: Tomlinson, J; Moore, J; Cooper, MS; Bujalska, I; Shahmanesh, M

• Publication status: Published
• Journal: Endocrinology
• Volume: 142
• Issue: 5
• Pages: 1982-1989
• Publication date: 2001-05-01
• DOI: 10.1210/en.142.5.1982
• EISSN: 1945-7170
• ISSN: 0013-7227
• Language: English
• Keywords: Organ Specificity; Hydroxysteroid Dehydrogenases; Interleukin-1; Adipose Tissue; Leptin; Prostaglandin D2; Cells, Cultured; Indinavir; 11-beta-Hydroxysteroid Dehydrogenases; Insulin-Like Growth Factor I; Isoenzymes; Cytokines; Tumor Necrosis Factor-alpha; Gene Expression Regulation; Stromal Cells; Humans