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Inhibition of merozoite invasion and transient de-sequestration by sevuparin in humans with Plasmodium falciparum malaria

Abstract:

Even with the best available treatment, the mortality from severe Plasmodium falciparum malaria remains high. Typical features at death are high parasite loads and obstructed micro- vasculature. Infected erythrocytes (IE) containing mature parasites bind to the host receptor heparan sulfate, which is also an important receptor for merozoite invasion. To block merozoite invasion has not previously been proposed as an adjunctive therapeutic approach but it may preclude the early expansion o...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0188754

Authors


Leitgeb, AM More by this author
Charunwatthana, P More by this author
Rueangveerayut, R More by this author
Uthaisin, C More by this author
Silamut, K More by this author
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Funding agency for:
Dondorp, AM
More from this funder
Funding agency for:
Dondorp, AM
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
12
Issue:
12
Pages:
Article: e0188754
Publication date:
2017-12-15
Acceptance date:
2017-11-16
DOI:
ISSN:
1932-6203
Pubs id:
pubs:796354
URN:
uri:d9765bbe-b06f-450e-8437-009a0e6f60f2
UUID:
uuid:d9765bbe-b06f-450e-8437-009a0e6f60f2
Local pid:
pubs:796354

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