Journal article
Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia
- Abstract:
-
Eosinophils are effectors in immunity to tissue helminths but also induce allergic immunopathology. Mechanisms of eosinophilia in non-mucosal tissues during infection remain unresolved. Here we identify a pivotal function of tissue macrophages (Mϕ) in eosinophil anti-helminth immunity using a BALB/c mouse intra-peritoneal Brugia malayi filarial infection model. Eosinophilia, via C-C motif chemokine receptor (CCR)3, was necessary for immunity as CCR3 and eosinophil impairments rendered mice su...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 5.8MB)
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- Publisher copy:
- 10.1371/journal.ppat.1006949
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Authors
Funding
Bill and Melinda Gates Foundation
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Pathogens Journal website
- Volume:
- 14
- Issue:
- 3
- Pages:
- e1006949
- Publication date:
- 2018-03-16
- Acceptance date:
- 2018-02-26
- DOI:
- EISSN:
-
1553-7366
- Pmid:
-
29547639
- Source identifiers:
-
831564
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:831564
- UUID:
-
uuid:d975515a-2b89-4dbe-8b63-1e41a702cb04
- Local pid:
- pubs:831564
- Deposit date:
- 2018-04-09
Terms of use
- Copyright holder:
- Turner et al
- Copyright date:
- 2018
- Notes:
- © 2018 Turner et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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