- Abstract:
-
Eosinophils are effectors in immunity to tissue helminths but also induce allergic immunopathology. Mechanisms of eosinophilia in non-mucosal tissues during infection remain unresolved. Here we identify a pivotal function of tissue macrophages (Mϕ) in eosinophil anti-helminth immunity using a BALB/c mouse intra-peritoneal Brugia malayi filarial infection model. Eosinophilia, via C-C motif chemokine receptor (CCR)3, was necessary for immunity as CCR3 and eosinophil impairments rendered mice su...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 5.8MB)
-
- Publisher copy:
- 10.1371/journal.ppat.1006949
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Pathogens Journal website
- Volume:
- 14
- Issue:
- 3
- Pages:
- e1006949
- Publication date:
- 2018-03-16
- Acceptance date:
- 2018-02-26
- DOI:
- EISSN:
-
1553-7366
- Pubs id:
-
pubs:831564
- URN:
-
uri:d975515a-2b89-4dbe-8b63-1e41a702cb04
- UUID:
-
uuid:d975515a-2b89-4dbe-8b63-1e41a702cb04
- Local pid:
- pubs:831564
- Language:
- English
- Keywords:
- Copyright holder:
- Turner et al
- Copyright date:
- 2018
- Notes:
- © 2018 Turner et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia
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Bill and Melinda Gates Foundation
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