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Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia

Abstract:

Eosinophils are effectors in immunity to tissue helminths but also induce allergic immunopathology. Mechanisms of eosinophilia in non-mucosal tissues during infection remain unresolved. Here we identify a pivotal function of tissue macrophages (Mϕ) in eosinophil anti-helminth immunity using a BALB/c mouse intra-peritoneal Brugia malayi filarial infection model. Eosinophilia, via C-C motif chemokine receptor (CCR)3, was necessary for immunity as CCR3 and eosinophil impairments rendered mice su...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1006949

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Role:
Author
ORCID:
0000-0002-2185-5476
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Role:
Author
ORCID:
0000-0002-2379-4945
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Role:
Author
ORCID:
0000-0002-3313-8650
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
ORCID:
0000-0003-1948-6779
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Role:
Author
ORCID:
0000-0002-8806-9891
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Bill and Melinda Gates Foundation More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
14
Issue:
3
Pages:
e1006949
Publication date:
2018-03-16
Acceptance date:
2018-02-26
DOI:
EISSN:
1553-7366
Pubs id:
pubs:831564
URN:
uri:d975515a-2b89-4dbe-8b63-1e41a702cb04
UUID:
uuid:d975515a-2b89-4dbe-8b63-1e41a702cb04
Local pid:
pubs:831564
Language:
English
Keywords:

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