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A systematic review of randomized controlled trials for plasma exchange in the treatment of thrombotic thrombocytopenic purpura.

Abstract:

The mainstay of treatment for thrombotic thrombocytopenic purpura (TTP) is plasma exchange (PE). A systematic review was undertaken to summarize the randomized controlled trial (RCT) evidence, to date, on PE as treatment for TTP. Seven randomized RCTs were identified till May 2005. A statistical reduction in mortality was found in patients receiving PE compared with patients receiving plasma infusion (relative risk 0.31, 95% confidence interval 0.12-0.79). No statistical difference in mortali...

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Publication status:
Published

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Authors


Brunskill, SJ More by this author
Benjamin, S More by this author
Stanworth, SJ More by this author
Murphy, MF More by this author
Journal:
Transfusion medicine (Oxford, England)
Volume:
17
Issue:
1
Pages:
17-35
Publication date:
2007-02-05
DOI:
EISSN:
1365-3148
ISSN:
0958-7578
URN:
uuid:d973ee92-7b1e-4136-b1c8-572d808131a9
Source identifiers:
191131
Local pid:
pubs:191131

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