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[The evidence for primary axonal loss in multiple sclerosis]

Abstract:

INTRODUCTION: At what stage in the pathogenesis of multiple sclerosis (MS) does the damage to axons occur, and why should there be any axon loss at all in what is thought to be principally an axon sparing demyelinating disease? A recently described new technique for investigating axon damage depends for its ability on the immunoreactivity of amiloid precursor protein (APP), which has been shown to be more sensitive than silver stains for detecting damaged axons. DEVELOPMENT: We used APP immun...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Revista de neurologia
Volume:
30
Issue:
12
Pages:
1203-1208
Publication date:
2000
EISSN:
1576-6578
ISSN:
0210-0010
URN:
uuid:d96f6fbc-8b9a-4bc3-aee8-95b5b93548b7
Source identifiers:
383085
Local pid:
pubs:383085

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